A RENIN-SECRETING TUMOR SENSITIVE TO CHANGES IN CENTRAL BLOOD-VOLUME (PRESUMABLY VIA SYMPATHETICS) BUT NOT TO CIRCULATING ANGIOTENSIN-II

被引：10

作者：

GORDON, RD ^{[1
]}

TUNNY, TJ ^{[1
]}

KLEMM, SA ^{[1
]}

FINN, WL ^{[1
]}

HAWKINS, PJ ^{[1
]}

HUNYOR, SJ ^{[1
]}

NORRIS, JJ ^{[1
]}

机构：

[1] ROYAL N SHORE HOSP,DEPT CARDIOVASC RES,ST LEONARDS,NSW 2065,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 03期

关键词：

aldosterone; angiotensin converting enzyme inhibitors; angiotensin II; atrial natriuretic peptide; computerized tomography; frusemide; juxta‐glomerular tumour; posture; renin; reninoma;

D O I：

10.1111/j.1440-1681.1990.tb01303.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. A 17 year old female presented with severe hypertension, hypokalaemia and elevated levels of plasma renin activity due to a renin‐secreting tumour. 2. Renin was responsive to posture, low sodium diet, saline infusion and frusemide, but relatively unresponsive to raising or lowering circulating levels of angiotensin II. 3. Renal venous renin levels lateralized to the side of the tumour with good contralateral suppression when measured with control of posture and avoidance of prior stimulation, with and without angiotensin converting enzyme inhibition. 4. Levels of atrial natriuretic peptide were elevated and responsive to posture, saline infusion and angiotensin infusion. 5. The tumour was evident on computerized tomography, but not on intravenous pyelography or renal angiography. 6. Responsiveness of renin secretion to normal stimuli in reninoma may make diagnosis difficult, and renal vein sampling under controlled conditions is necessary. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：185 / 189

页数：5

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