COMPARATIVE IN-VITRO KILLING ACTIVITY OF MEROPENEM VERSUS IMIPENEM AGAINST MULTIRESISTANT NOSOCOMIAL PSEUDOMONAS-AERUGINOSA

被引：3

作者：

GIAMARELLOSBOURBOULIS, EJ ^{[1
]}

GRECKA, P ^{[1
]}

GIAMARELLOU, H ^{[1
]}

机构：

[1] UNIV ATHENS,LAIKO GEN HOSP,SCH MED,DEPT PROPEDEUT MED 1,GR-11527 ATHENS,GREECE

来源：

JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 03期

关键词：

PSEUDOMONAS AERUGINOSA; MEROPENEM; IMIPENEM; CARBAPENEM;

D O I：

10.1179/joc.1995.7.3.179

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to compare the in vitro killing activity of meropenem and imipenem against multiresistant P.aeruginosa 14 strains were used, All nosocomial isolates were susceptible to meropenem and imipenem minimum inhibitory concentration (MIG less than or equal to 4 mu g/ml) and resistant to at least two other antimicrobial agents of diverse chemical class with antipseudomonal activity. Forty-two killing curves were performed by exposing a 5 X 10(5) CFU/ml log-phase inoculum to 1x minimum bactericidal concentration (MBC) of each carbapenem Meropenem was found to possess a slower killing rate than imipenem over the first 5 hours of P.aeruginosa exposure, but to be equally effective as imipenem after 24 hours of incubation. Forty percent and 11.1% of P.aeruginosa strains developed resistance to imipenem and meropenem respectively after a 24-hour exposure to carbapenem. The authors speculate about the underlying mechanisms explaining the higher rate of resistance development to imipenem than to meropenem.

引用

页码：179 / 183

页数：5

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