ACROMEGALY

被引：13

作者：

BARKAN, AL

机构：

[1] Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 06期

关键词：

D O I：

10.1016/1043-2760(92)90029-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the majority of cases, acromegaly is due to GH hypersecretion by a somatotroph pituitary tumor. The etiology of acromegaly is not known, and may be related to GHRH hypersecretion, intrinsic pituitary defect, or a combination thereof Recent physiologic data and molecular biology techniques provide insights into the pathophysiology of this condition. Treatment options include surgery, radiation, and judicious administration of pharmacologic compounds inhibiting GH secretion and tumor growth.

引用

收藏

页码：205 / 210

页数：6

相关论文

共 41 条

[1] A CASE FOR HYPOTHALAMIC ACROMEGALY - A CLINICOPATHOLOGICAL STUDY OF 6 PATIENTS WITH HYPOTHALAMIC GANGLIOCYTOMAS PRODUCING GROWTH HORMONE-RELEASING FACTOR [J].

ASA, SL ;

SCHEITHAUER, BW ;

BILBAO, JM ;

HORVATH, E ;

RYAN, N ;

KOVACS, K ;

RANDALL, RV ;

LAWS, ER ;

SINGER, W ;

LINFOOT, JA ;

THORNER, MO ;

VALE, W .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (05) :796-803

[2]

ASA SL, 1990, P SOC EXP BIOL MED, V193, P232

[3] ACROMEGALY - DIAGNOSIS AND THERAPY [J].

BARKAN, AL .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1989, 18 (02) :277-310

[4] PREOPERATIVE TREATMENT OF ACROMEGALY WITH LONG-ACTING SOMATOSTATIN ANALOG SMS-201-995 - SHRINKAGE OF INVASIVE PITUITARY MACROADENOMAS AND IMPROVED SURGICAL REMISSION RATE [J].

BARKAN, AL ;

LLOYD, RV ;

CHANDLER, WF ;

HATFIELD, MK ;

GEBARSKI, SS ;

KELCH, RP ;

BEITINS, IZ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (05) :1040-1048

[5] INCREASED GROWTH-HORMONE PULSE FREQUENCY IN ACROMEGALY [J].

BARKAN, AL ;

STRED, SE ;

RENO, K ;

MARKOVS, M ;

HOPWOOD, NJ ;

KELCH, RP ;

BEITINS, IZ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (06) :1225-1233

[6] INCREASED GH RESPONSE TO GHRH IN NORMAL TALL MEN [J].

BATRINOS, M ;

GEORGIADIS, E ;

PANITSAFAFLIA, C ;

STRATIGOPOULOS, S .

CLINICAL ENDOCRINOLOGY, 1989, 30 (01) :13-17

[7] PLACENTAL AND PITUITARY GROWTH-HORMONE SECRETION DURING PREGNANCY IN ACROMEGALIC WOMEN [J].

BECKERS, A ;

STEVENAERT, A ;

FOIDART, JM ;

HENNEN, G ;

FRANKENNE, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 71 (03) :725-731

[8] GROWTH HORMONE-RELEASING FACTOR STIMULATES PROLIFERATION OF SOMATOTROPHS INVITRO [J].

BILLESTRUP, N ;

SWANSON, LW ;

VALE, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6854-6857

[9] PITUITARY HYPERPLASIA AND GIGANTISM IN MICE CAUSED BY A CHOLERA-TOXIN TRANSGENE [J].

BURTON, FH ;

HASEL, KW ;

BLOOM, FE ;

SUTCLIFFE, JG .

NATURE, 1991, 350 (6313) :74-77

[10]

BUTTERWORTH BE, 1991, P SOC EXP BIOL MED, V198, P683

← 1 2 3 4 5 →