EFFECTS OF 2,3,7,8-TETRACHLORODIBENZOFURAN (TCDF) ON THE IMMUNE SYSTEM IN GUINEA-PIGS

被引：14
作者：
LUSTER, MI
FAITH, RE
LAWSON, LD
机构：
[1] National Institutes of Health National, Institute of Environmental Health Sciences, Research Triangle Park, NC
来源：
DRUG AND CHEMICAL TOXICOLOGY | 1979年 / 2卷 / 1-2期
关键词：
D O I：
10.3109/01480547908993181
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effects of TCDF exposure on the immune system were investigated in Hartley guinea pigs. TCDF was administered by gavage at doses of 0.05, 0.17, 0.5 or 1.0 ug/kg body weight once weekly for six weeks. Thymus/body weight ratios were suppressed in the higher dosage groups. Parameters of cell-mediated and humoral immune function were investigated. TCDF modestly suppressed cell-mediated immune function and had slight effects on humoral-mediated functions. TCDF immunosuppression appears similar to that induced following exposure to TCDD. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：49 / 60
页数：12
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