INHIBITORY POTENCY OF VARIOUS PEPTIDES ON ENKEPHALINASE ACTIVITY FROM MOUSE STRIATUM

被引：73

作者：

FOURNIEZALUSKI, MC ^{[1
]}

PERDRISOT, R ^{[1
]}

GACEL, G ^{[1
]}

SWERTS, JP ^{[1
]}

ROQUES, BP ^{[1
]}

SCHWARTZ, JC ^{[1
]}

机构：

[1] INSERM,CTR PAUL BROCA,UNITE NEUROBIOL 109,F-75014 PARIS,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)90593-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of peptides chemically unrelated to enkephalins are relatively good inhibitors (IC50 in the micromoLar range) of enkephalinase" activity i.e. of the peptidase releasing Tyr-Gly-Gly from Leu-enkephalin. Its specificity has been also reinvestigated with a series of Met-enkephalin analogues. The poor recognition of several analogues by this inactivating enzyme might account for their enhanced biological activity. © 1979."

引用

页码：130 / 135

页数：6

共 25 条

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