ALPHA-FETOPROTEIN IN CONGENITAL HYPOTHYROIDISM

被引：0
作者：
MENGRELI, C
SARAFIDOU, E
PETMEZAKI, S
PANTELAKIS, S
机构：
[1] CHILDRENS HOSP,MATERN UNIT MITERA,ATHENS,GREECE
[2] CHILDRENS HOSP,PEDIAT UNIT AGHIA SOPHIA,ATHENS,GREECE
来源：
BIOLOGY OF THE NEONATE | 1990年 / 58卷 / 06期
关键词：
ALPHA-FETOPROTEIN; CONGENITAL HYPOTHYROIDISM; TRANSIENT HYPERTHYROTROPINEMIA;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Alpha-Fetoprotein (alpha-FP) was measured in dried blood spots from normal, congenital hypothyroid (CH) and transient hyperthyrotropinemic (TH) newborns as well as in serum from CH and TH babies together with thyroxine, triiodothyronine and thyrotropin. The half-life of alpha-FP had a median value of 12 days in the CH cases and 4.9 days in the TH cases. alpha-FP was significantly higher in the CH group before treatment and showed a significant rise after discontinuation of thyroxine therapy. It would appear that thyroid hormones influence alpha-FP metabolism and that a hypothyroid environment results in increased alpha-FP levels.
引用
收藏
页码：326 / 333
页数：8
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