SUBSTITUTION OF LYSINE FOR ARGININE IN THE N-TERMINAL 217TH AMINO-ACID RESIDUE OF THE H-GAMMA-II OF STAPHYLOCOCCAL GAMMA-HEMOLYSIN LOWERS THE ACTIVITY OF THE TOXIN

被引：8

作者：

SUDO, K ^{[1
]}

CHOORIT, W ^{[1
]}

ASAMI, I ^{[1
]}

KANEKO, J ^{[1
]}

MURAMOTO, K ^{[1
]}

KAMIO, Y ^{[1
]}

机构：

[1] TOHOKU UNIV, FAC AGR, DEPT APPL BIOL CHEM, AOBA KU, SENDAI, MIYAGI 981, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 09期

关键词：

D O I：

10.1271/bbb.59.1786

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The staphyloccocal toxin gamma-hemolysin consists of two protein components, LukF and H gamma II. Staphylococcus aureus P83 was found to have five components, LukF, LukF-PV, LukM, LukS, and H gamma II for leukocidin or gamma-hemolysin. H gamma II of S. aureus P83 was demonstrated to be a naturally-occurring analogous molecule of H gamma II [H gamma II(P83)], in which the 217th arginine residue was replaced by lysine. The H gamma II(P83) showed about 50% of the hemolytic activity of normal H gamma II in the presence of LukF.

引用

页码：1786 / 1789

页数：4