THE SELENIUM MEDIATED DE-IODINATION OF IODOPHENOLS - A MODEL FOR THE MECHANISM OF 5'-THYRONINE DEIODINASE

被引：18

作者：

BECK, C ^{[1
]}

JENSEN, SB ^{[1
]}

REGLINSKI, J ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,GLASGOW G1 1XL,SCOTLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80360-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The de-iodination of aryl-phenols by benzeneselenol is investigated as a model of the seleno-Protein, 5'-thyronine de-iodinase. The results suggest that the mechanism involves the stabilisation of the ketonic tautomer of thyroxine (T4) prior to the abstraction of an iodine by RSe-. The RSeI formed can then be reduced by a thiol co-factor to regenerate the active enzyme.

引用

页码：1353 / 1356

页数：4

共 8 条

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