NEW SYNTHETIC METHODOLOGY FOR THE SYNTHESIS OF 7-SUBSTITUTED TETRAHYDROAZEPIN-2-ONES

被引：17
作者：
EVANS, PA
HOLMES, AB
RUSSELL, K
机构：
[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CTR MOLEC RECOGNIT,CAMBRIDGE CB2 1EW,ENGLAND
[2] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 23期
关键词：
D O I：
10.1039/p19940003397
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Claisen rearrangement of the vinyl substituted ketene aminals 2 (R=CH(2)CHMe(2), CH(2)OSiBu(t)Me(2)) which were generated in situ by selenoxide elimination of the aminal precursors 3 in the presence of 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU) furnished the enantiomerically pure 7-substituted tetrahydroazepin-2-ones 1.
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页码：3397 / 3409
页数：13
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