ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION USING INTRA-ORAL IVABRADINE: A CLINICAL STUDY

BACKGROUND AND OBJECTIVES: Rapid and dramatic hemodynamic changes which adversely affect the patient may occur during laryngoscopy and intubation. The present study evaluates the effect of oral ivabradine on the hemodynamics during laryngoscopy and endotracheal intubation in patients undergoing surgical procedures under general anesthesia. METHODS: A prospective randomized, single blinded study was conducted in 50 ASA-I adult patients undergoing various procedures under general anesthesia. The patients were randomly divided into two groups. Patients in group I (test group) (n= 25) received oral Ivabradine, 5mg one tab at 6.00pm on the evening before the day of surgery and one 5mg tab one hour before intubation. Patients in group II (control group) (n= 25) received placebo. Hemodynamic variables were recorded from pre-operative period to 10 minutes after intubation. RESULTS: There was not a very significant increase in the hemodynamic parameters in response to laryngoscopy and intubation in the Test group, when compared to the control group and the minimal raise also returned to baseline immediately within a minute. INTERPRETATIONS AND CONCLUSION: Ivabradine is an extremely useful drug to prevent abnormal increase in heart rate and minimizes the extent of hypertension seen during laryngoscopy and endotracheal intubation.