Transverse myelitis is a rare focal inflammation of the spinal cord. Multiple etiologies have been identified including autoimmune diseases, mainly systemic lupus erythematosus and Sjgren' syndrome. It can occur in an acute or subacute clinical onset, with the acute presentation having a worse prognosis. A nearly diagnosis and intensive treatment are important features recommended in these patients. We present three cases with transverse myelitis associated with autoimmune diseases. We discuss different clinical manifestations, association with auto antobodies, radiologic findings, and therapeuticand prognostic issues. (C) 2013 Elsevier Espana, S.L.U. All rights reserved.