Oxidative stress response induced by chemotherapy in leukemia treatment

被引：53

作者：

Zhang, Jin ^{[1
]}

Lei, Wen ^{[2
]}

Chen, Xiaohui ^{[3
]}

Wang, Shibing ^{[4
]}

Qian, Wenbin ^{[2
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Hematol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Coll Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Dept Hematol, Affiliated Hosp, Hangzhou 310015, Zhejiang, Peoples R China

[4] Zhejiang Prov Peoples Hosp, Clin Res Inst, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2018年 / 8卷 / 03期

基金：

中国国家自然科学基金;

关键词：

oxidative stress; reactive oxygen species; leukemogenesis; chemotherapy;

D O I：

10.3892/mco.2018.1549

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oxidative stress (OS) has been linked to the etiology and development of leukemia as reactive oxygen species (ROS) and free radicals have been implicated in leukemogenesis. OS has beneficial and deleterious effects in the pathogenesis and progression of leukemia. High-dose chemotherapy, which is frequently used in leukemia treatment, is often accompanied by ROS-induced cytotoxicity. Thus, the utilization of chemotherapy in combination with antioxidants may attenuate leukemia progression, particularly for cases of refractory or relapsed neoplasms. The present review focuses on exploring the roles of OS in leukemogenesis and characterizing the associations between ROS and chemotherapy. Certain examples of treatment regimens wherein antioxidants are combined with chemotherapy are presented, in order to highlight the importance of antioxidant application in leukemia treatment, as well as the conflicting opinions regarding this method of therapy. Understanding the underlying mechanisms of OS generation will facilitate the elucidation of novel approaches to leukemia treatment.

引用

页码：391 / 399

页数：9

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