BDNF MESSENGER-RNA EXPRESSION IN THE DEVELOPING RAT-BRAIN FOLLOWING KAINIC ACID-INDUCED SEIZURE ACTIVITY

被引：165

作者：

DUGICHDJORDJEVIC, MM ^{[1
]}

TOCCO, G ^{[1
]}

WILLOUGHBY, DA ^{[1
]}

NAJM, I ^{[1
]}

PASINETTI, G ^{[1
]}

THOMPSON, RF ^{[1
]}

BAUDRY, M ^{[1
]}

LAPCHAK, PA ^{[1
]}

HEFTI, F ^{[1
]}

机构：

[1] UNIV SO CALIF, DEPT BIOL SCI, LOS ANGELES, CA 90089 USA

来源：

NEURON | 1992年 / 8卷 / 06期

关键词：

D O I：

10.1016/0896-6273(92)90133-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) mRNA expression was studied in the hippocampus at various developmental stages in normal rats and following kainic acid (KA)-induced seizure activity. Systemic administration of KA strongly elevated BDNF mRNA levels in all hippocampal subregions after postnatal day 21. In contrast, even though KA induced intense behavioral seizure activity at postnatal day 8, the seizures were not associated with elevations of BDNF mRNA levels, indicating a clear dissociation between behavioral seizures and increases in BDNF mRNA levels and contradicting the view that BDNF mRNA expression is principally regulated by neuronal activity. In the dentate gyrus at postnatal day 13, intense BDNF mRNA expression was limited to a defined area at the border between granule cell and molecular layers, suggesting the possibility that segregation of BDNF mRNA into defined subcellular compartments may play a role in establishing the well-delineated patterns of innervation in the hippocampus.

引用

页码：1127 / 1138

页数：12

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