EXPERIMENTAL AUTOIMMUNE ADRENALITIS - A MURINE MODEL FOR ADDISONS-DISEASE

被引：16

作者：

FUJII, Y ^{[1
]}

KATO, N ^{[1
]}

KITO, J ^{[1
]}

ASAI, J ^{[1
]}

YOKOCHI, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BACTERIOL,NAGOYA,AICHI 466,JAPAN

来源：

AUTOIMMUNITY | 1992年 / 12卷 / 01期

关键词：

AUTOIMMUNE ADRENALITIS; ADDISONS DISEASE; LIPOPOLYSACCHARIDE; LPS; KLEBSIELLA;

D O I：

10.3109/08916939209146129

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental autoimmune adrenalitis was produced in mice by immunizing 8 times or more at intervals of 30 days with syngeneic adrenal extract mixed with Klebsiella 03 lipopolysaccharide (KO3 LPS) as a potent adjuvant. The cortex regions of the adrenal glands after the 8th injection were definitely infiltrated with polymorphonuclear leukocytes (PMN). The main infiltrates in the lesions after the 9th injection were replaced by mononuclear cells, such as small lymphocytes and macrophages, and further by fibrous connective tissues. There were no histological changes in the medullary regions. The repeated immunization developed the delayed type hypersensitivity to adrenal extract and production of anti-adrenocortical autoantibody in those immunized mice. Moreover, the adrenalitis could be produced in normal mice by transfer of spleen cells from hyperimmunized mice, suggesting the critical role of the cell-mediated immunity. This experimental model might be useful to study immunological phenomena in the pathogenesis of Addison's disease. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：47 / 52

页数：6

共 24 条

[11]

Nakashima I., Kato N., Microbial adjuvant and autoimmunity. I. Induction of antibody responses to syngeneic tissue extracts in mice treated with capsular polysaccharide of, Klebsiella pneumoniae. Microbiol Immunol, 21, pp. 279-288, (1977)

[12]

Nakashima I., Yokochi T., Kato N., Asai I., Microbial adjuvant and autoimmunity. II. Production of lesions in mice immunized with syngeneic tissues extracts together with the capsular polysaccharide of Klebsiella pneumoniae, Microbiol Immunol, 27, pp. 279-288, (1977)

[13]

Yokochi T., Oka K., Iwata H., Miyadai T., Kimura Y., Kato N., Characterization of auto antigens relevant to autoimmune ophthalmitis and thyroiditis in mice immunized with the syngeneic tissue extracts and Klebsiella 03 lipopolysaccharide, Microbiol Immunol, 31, pp. 1025-1032, (1987)

[14]

Iwase K., Fujii Y., Nakashima I., Kato N., Fujino Y., Kawashima H., Mochizuki M., A new method for induction of experimental autoimmune uveoretinitis (EAU) in mice, Curr Eye Res, 9, pp. 207-216, (1990)

[15]

Yokochi T., Nakashima I., Kato N., Asai J., Microbial adjuvant and autoimmunity. III. Histological studies of development of experimental autoimmune thyroiditis in mice immunized with the syngeneic thyroid extract together with the capsular polysaccharide of, Klebsiella pneumoniae. Microbiol Immunol, 22, pp. 619-630, (1978)

[16]

Yokochi T., Nakashima I., Kato N., Miyadai T., Kimura Y., Microbial adjuvant and autoimmunity. V. The induction of thyroid lesions in syngeneic X–irradiated mice by the transfer of spleen cells from mice immunized with thyroid extract and, Klebsiella pneumoniae. Microbiol Immunol, 30, pp. 553-559, (1986)

[17]

Yamaki K., Ohta M., Nakashima I., Noda A., Asai J., Kato N., Microbial adjuvant and autoimmunity. IV. Production of lesions in the exocrine pancreas of mice by repeated injection of syngeneic pancreatic extract together with the capsular poly saccharide of, Klebsiella pneumoniae. Microbiol Immunol, 24, pp. 945-956, (1980)

[18]

Kuriki J., Murakami H., Kakumu S., Sakamoto N., Yokochi T., Nakashima I., Kato N., Experimental autoimmune hepatitis in mice after immunization with syngeneic liver proteins together with the polysaccharide of, Klebsiella pneumoniae. Gastroenterology, 84, pp. 596-603, (1983)

[19]

Kato T., Yamada H., Yokochi T., Nakashima I., Kato N., Experimental autoimmune hemolytic anemia in mice induced by repeated immunization with ultrasonicated syngeneic erythrocytes together with Klebsiella O3 lipopolysaccharide, Acta Haematol Jpn, 47, pp. 838-845, (1984)

[20]

Fujii Y., Yokochi T., Nakashima I., Asai J., Kato N., Experimental autoimmune orchitis in mice immunized with a mixture of syngeneic testis extract and Klebsiella 03 lipopolysaccharide as a potent adjuvant, Med Microbiol Immunol, 180, pp. 1-14, (1991)

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