BULBAR AND PSEUDOBULBAR PALSY COMPLICATING THERAPY WITH HIGH-DOSE CYTOSINE-ARABINOSIDE IN CHILDREN WITH LEUKEMIA

被引：6

作者：

SHAW, PJ ^{[1
]}

PROCOPIS, PG ^{[1
]}

MENSER, MA ^{[1
]}

BERGIN, M ^{[1
]}

ANTONY, J ^{[1
]}

STEVENS, MM ^{[1
]}

机构：

[1] CHILDRENS HOSP,DEPT NEUROL,CAMPERDON,NSW 2050,AUSTRALIA

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1991年 / 19卷 / 02期

关键词：

ARA-C; NEUROLOGICAL COMPLICATIONS; ACUTE LEUKEMIA;

D O I：

10.1002/mpo.2950190210

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three of 38 children given high-dose cytosine arabinoside therapy developed a previously undescribed complication. Neurological problems are a frequent occurrence in patients given this therapy, particularly cerebellar ataxia, but the development of bulbar and pseudobulbar palsy has not been reported. In two of these cases, it was sufficiently marked for the course of treatment to be curtailed and occurred at a relatively low cumulative dose of the drug. Neurotoxicity can occur at any time using high-dose cytosine therapy.

引用

页码：122 / 125

页数：4

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