THE ANTIDEPRESSANT POTENTIAL OF ORAL S-ADENOSYL-L-METHIONINE

被引：53

作者：

ROSENBAUM, JF

FAVA, M

FALK, WE

POLLACK, MH

COHEN, LS

COHEN, BM

ZUBENKO, GS

机构：

[1] UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,PITTSBURGH,PA 15213

[2] CARNEGIE MELLON UNIV,MELLON INST,DEPT BIOL SCI,PITTSBURGH,PA 15213

[3] MCLEAN HOSP,BELMONT,MA 02178

[4] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 81卷 / 05期

关键词：

depression; S‐adenosyl‐l‐methionine;

D O I：

10.1111/j.1600-0447.1990.tb05476.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

S‐adenosyl‐l‐methionine (SAMe), a naturally occurring brain metabolite, has previously been found to be effective and tolerated well in parenteral form as a treatment of major depression. To explore the antidepressant potential of oral SAMe, we conducted an open trial in 20 outpatients with major depression, including those with (n= 9) and without (n= 11) prior history of antidepressant nonresponse. The group as a whole significantly improved with oral SAMe: 7 of 11 non‐treatment‐resistant and 2 of 9 treatment‐resistant patients experienced full antidepressant response. Side effects were mild and transient. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：432 / 436

页数：5

共 33 条

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