EFFECTS OF VANADATE ON CARDIAC CONTRACTION AND ADENYLATE-CYCLASE

被引：99

作者：

GRUPP, G

GRUPP, I

JOHNSON, CL

WALLICK, ET

SCHWARTZ, A

机构：

[1] UNIV CINCINNATI,DEPT PHYSIOL,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,DEPT CELL BIOPHYS,CINCINNATI,OH 45267

[3] UNIV CINCINNATI,DEPT INTERNAL MED,CINCINNATI,OH 45267

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)92068-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vanadate produces a positive inotropic effect on ventricular muscle from rat, rabbit, guinea pig and cat; a positive inotropic effect on the atria of rat and rabbit, but a negative inotropic effect on the atria of guinea pig and cat. The effects of vanadate are completely reversible and occur in a concentration range of 10-5M to 10-3M. In this same concentration range, vanadate also causes a marked activation of cardiac adenylate cyclase suggesting that the positive inotropic action might be due in part to an elevation of cyclic AMP levels. The effects of vanadate are not influenced by alprenolol, cimetidine, or mepyramine, indicating a lack of involvement of β-adrenergic or histamine H2 and H1 receptors. © 1979.

引用

页码：440 / 447

页数：8

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