PRESERVATION OF ANTIMYOSIN ANTIBODY-ACTIVITY AFTER COVALENT COUPLING TO LIPOSOMES

被引：113
作者：
TORCHILIN, VP [1 ]
KHAW, BA [1 ]
SMIRNOV, VN [1 ]
HABER, E [1 ]
机构：
[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,DEPT MED,CARDIAC UNIT,BOSTON,MA 02114
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期
关键词：
D O I：
10.1016/0006-291X(79)92123-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A procedure for coupling liposomes to a target specific macromolecular species, anticanine cardiac myosin antibodies, was developed. The anticanine cardiac myosin antibodies covalently coupled to liposomes were shown to retain the specific antibody activity in vitro for the homologous radioiodinated antigen. Radioisotopes can be transported inside such liposome-antibody complexes and were shown experimentally to localize in acute canine myocardial infarction. This new method of coupling of liposome to target-specific agents could provide a novel and highly specific means of transporting radioisotopes or pharmaceuticals protected within the liposomes to selected target organs. © 1979.
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页码：1114 / 1119
页数：6
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