NUCLEATION OF MICROTUBULE ASSEMBLY BY A GAMMA-TUBULIN-CONTAINING RING COMPLEX

被引：721

作者：

ZHENG, YX ^{[1
]}

WONG, ML ^{[1
]}

ALBERTS, B ^{[1
]}

MITCHISON, T ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA

来源：

NATURE | 1995年 / 378卷 / 6557期

关键词：

D O I：

10.1038/378578a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.

引用

页码：578 / 583

页数：6

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