MECHANISMS IN IGE-DEPENDENT ANAPHYLAXIS TO ANESTHETIC DRUGS

被引：21
作者：
BALDO, BA
FISHER, MM
机构：
[1] Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, St Leonards
[2] Intensive Therapy Unit, Royal North Shore Hospital of Sydney, St Leonards
来源：
ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 1993年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0750-7658(05)81022-6
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The discovery of IgE antibodies to neuromuscular blocking drugs, to thiopentone and narcotics, particularly morphine, reinforced earlier beliefs formed from skin test and other clinical findings that many << anaphylactoid >> reactions to drugs were true type 1 immediate hypersensitivity reactions. Immunochemical studies established the fine structural specificities of the drug-reactive IgE antibodies and provided an explanation in molecular terms for a number of observed clinical cross-reactions. Subtleties in interpreting relationships between skin tests and IgE radioimmunoassays are pointed out and mechanisms of drug-induced mediator release, persistence of IgE antibodies and the nature of the sensitizing sources are discussed.
引用
收藏
页码：131 / 140
页数：10
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