MECHANISTIC STUDIES ON PREGNENE SIDE-CHAIN CLEAVAGE ENZYME (17-ALPHA-HYDROXYLASE-17,20-LYASE) USING O-18

被引：44

作者：

MILLER, SL ^{[1
]}

WRIGHT, JN ^{[1
]}

CORINA, DL ^{[1
]}

AKHTAR, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT BIOCHEM,MED & BIOL SCI BLDG,BASSETT CRESCENT E,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 03期

关键词：

D O I：

10.1039/c39910000157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the conversion of pregnenolone 1 into dehydroisoandrosterone 3 and 3-beta-hydroxyandrosta-5,16-diene 5 an atom of oxygen from O2 is incorporated into the side chain released as acetate; during the conversions the C-21 methyl hydrogens of the precursor are not disturbed, the status of 16-alpha and 17-alpha hydrogen atoms during the conversions is also defined.

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页码：157 / 159

页数：3

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