EFFECT OF CYCLIC-AMP ON HISTAMINE-RELEASE INDUCED BY COMPOUND 48-80

被引：15

作者：

ENNIS, M ^{[1
]}

PEARCE, FL ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL, DEPT CHEM, LONDON WC1H 0AJ, ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 60卷 / 04期

关键词：

D O I：

10.1159/000232377

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Bu2 cAMP(N6,O2'-dibutyryl adenosine-3',5'-cyclic monophosphate) inhibited the response of rat peritoneal mast cells to compound 48/80 in the presence of calcium ions. In the absence of calcium, the nucleotide partially prevented the desensitization induced by chelating agents. The response of cells, allowed to accumulate Bu2 cAMP in the presence of calcium (to avoid depletion of intracellular stores of the ion) and then challenged in the absence of extracellular calcium, was also inhibited. These results are discussed in terms of the postulated effects of Bu2 cAMP on the calcium-gating mechanism operative in histamine secretion.

引用

页码：461 / 464

页数：4

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