DEXAMETHASONE PRETREATMENT REDUCES THE PSYCHOMOTOR STIMULANT EFFECTS INDUCED BY COCAINE AND AMPHETAMINE IN MICE

被引：5

作者：

CAPASSO, A ^{[1
]}

DIGIANNUARIO, A ^{[1
]}

LOIZZO, A ^{[1
]}

PIERETTI, S ^{[1
]}

SORRENTINO, L ^{[1
]}

机构：

[1] IST SUPER SANITA,ROME,ITALY

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 06期

关键词：

COCAINE; D-AMPHETAMINE; DEXAMETHASONE; LOCOMOTOR ACTIVITY; MICE;

D O I：

10.1016/0278-5846(95)00197-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The present study examined a comparison of the effect of DEX on psychomotor stimulant effects of cocaine and amphetamine in mice by using the locomotor activity test. 2. Cocaine (10 mg/kg/i.p.) and amphetamine (5 mg/kg/i.p.) increased markedly locomotor activity of mice whereas DEX per se (0.1-1.0-10 mg/kg/i.p.) did not modify the activity of control mice. 3. DEX pretreatment decreased the stimulating effects induced both by cocaine and amphetamine but no consistent dose-related effects were observed. 4. The results suggest that DEX may play an important role on the stimulating effects of cocaine and amphetamine and that it may be of some utility in the clinical management of psychostimulants abuse.

引用

页码：1063 / 1079

页数：17

共 54 条

[1]

BALDESSARINI R J, 1990, P383

[2]

BUXBAUM DM, 1973, J PHARMACOL EXP THER, V185, P317

[3] MODULATION OF THE LOCOMOTOR RESPONSE TO AMPHETAMINE BY CORTICOSTERONE [J].