SYNTHESES OF SOME NITROIMIDAZOLE SUBSTITUTED BORONIC ACIDS - PRECURSORS TO TC-99M COMPLEXES WITH POTENTIAL FOR IMAGING HYPOXIC TISSUE

被引：13

作者：

RAJU, N ^{[1
]}

RAMALINGAM, K ^{[1
]}

NOWOTNIK, DP ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,1 SQUIBB DR,NEW BRUNSWICK,NJ 08903

来源：

TETRAHEDRON | 1992年 / 48卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)88329-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of nitroimidazole substituted alkyl and aryl-boronic acids were synthesized as precursors to technetium-99m complexes under investigation as potential imaging agents of hypoxia. Compounds were prepared with the nitro group either in the 2-or 4-position of the imidazole, and with a variety of spacer groups placed between the imidazole and boronic acid

引用

页码：10233 / 10238

页数：6

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