DIRECT ANALYSIS OF KRYPTOFIX 2.2.2 IN 18FDG BY GAS-CHROMATOGRAPHY USING A NITROGEN-SELECTIVE DETECTOR

被引：18
|
作者：
FERRIERI, RA
SCHLYER, DJ
ALEXOFF, DL
FOWLER, JS
WOLF, AP
机构：
[1] Department of Chemistry, Brookhaven National Laboratory, Upton
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 03期
关键词：
D O I：
10.1016/0969-8051(93)90061-X
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A method is described for the direct measurement of Kryptofix 2.2.2 levels in F-18DG preparations dissolved in isotonic saline using gas chromatography coupled with a nitrogen-selective detector. The cryptand can be eluted intact in 2 min time from a short megabore capillary column, and detected at levels as low as 0.25 mug/mL. This method offers rapid, quantitative and sensitive detection of Kryptofix 2.2.2 levels in F-18DG thus making it amenable to routine quality assurance testing.
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页码：367 / 369
页数：3
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