RADARIN-A, RADARIN-B, RADARIN-C, AND RADARIN-D - NEW ANTIINSECTAN AND CYTOTOXIC INDOLE DITERPENOIDS FROM THE SCLEROTIA OF ASPERGILLUS-SULPHUREUS

被引：20

作者：

LAAKSO, JA

GLOER, JB

WICKLOW, DT

DOWD, PF

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

[2] USDA ARS,CTR AGR UTILIZAT RES,PEORIA,IL 61604

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 01期

关键词：

D O I：

10.1021/jo00027a026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new indole diterpenoids, radarins A-D (3-6), have been isolated from the sclerotia of Aspergillus sulphureus by chromatographic separation of the CH2Cl2 extract. The structure of radarin A (3) was determined using extensive high-field 2D NMR experiments. Radarins B-D (4-6) were assigned by analysis of NMR data, spectral comparison to 3, and/or by chemical interconversion. Compound 3 has the most potent activity against the corn earworm Helicoverpa zea and exhibits significant cytotoxicity in assays against three human solid tumor cell lines.

引用

页码：138 / 141

页数：4

共 18 条

[1]

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