DIMINISHED RESPONSE TO RECOMBINANT HEPATITIS-B VACCINE IN HOMOSEXUAL MEN WITH HIV ANTIBODY - AN INDICATOR OF POOR PROGNOSIS

被引：58

作者：

LOKE, RHT

MURRAYLYON, IM

COLEMAN, JC

EVANS, BA

ZUCKERMAN, AJ

机构：

[1] CHARING CROSS HOSP,DEPT GASTROENTEROL,FULHAM PALACE RD,LONDON W6 8RF,ENGLAND

[2] CHARING CROSS HOSP,DEPT VIROL,LONDON W6 8RF,ENGLAND

[3] CHARING CROSS HOSP,DEPT GENITOURINARY MED,LONDON W6 8RF,ENGLAND

[4] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED MICROBIOL,LONDON WC1E 7HT,ENGLAND

[5] UNIV LONDON LONDON SCH HYG & TROP MED,WHO COLLABORATING CTR REFERENCE & RES VIRAL HEPATITIS,LONDON WC1E 7HT,ENGLAND

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 31卷 / 02期

关键词：

AIDS prognosis; hepatitis B vaccination; HIV;

D O I：

10.1002/jmv.1890310207

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three doses of a recombinant DNA HBV vaccine (MSD) were given to healthy male homosexuals. Seventy‐eight out of 104 (77.6%) participants had detectable antibody (anti‐HBs) two months after the third dose. Seroconversion occurred in only 9 out of 27 subjects (33.3%) who were anti‐HIV positive compared with 69 out of 77 (89.6%) who were negative (χ2 = 30.8; P < .001). Fifteen of the 18 anti‐HIV positive who did not mount an antibody response to the hepatitis B vaccine (anti‐HBs) later progressed to persistent generalised lymphadenopathy syndrome (5), AIDS‐related complex (5), and AIDS (5). Only one of the nine anti‐HIV positive anti‐HBs responders developed PGL (χ2 = 10.14; P < .005). Our results show that anti‐HIV positive homosexuals are poor responders to the recombinant hepatitis B vaccine and anti‐HIV positive non‐responders are more likely to develop clinically apparent HIV infection. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：109 / 111

页数：3

共 13 条

[1] SHOULD HOMOSEXUALS BE VACCINATED AGAINST HEPATITIS-B VIRUS - COST AND BENEFIT ASSESSMENT [J].