SEPARATION OF POLYMYXINS AND OCTAPEPTINS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：29
作者：
TERABE, S [1 ]
KONAKA, R [1 ]
SHOJI, J [1 ]
机构：
[1] SHIONOGI & CO LTD,RES LAB,OSAKA 553,JAPAN
来源：
JOURNAL OF CHROMATOGRAPHY | 1979年 / 173卷 / 02期
关键词：
D O I：
10.1016/S0021-9673(00)92299-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Seventeen decapeptide antibiotics of the polymyxin group and nine octapeptide antibiotics of the octapeptin group have been successfully separated on a commercial reversed-phase material with tartrate buffer-acetonitrile containing sodium 1-butanesulphonate and sodium sulphate as the mobile phase. All of the components of EM49 (a complex of octapeptins A and B) were preparatively separated by use of a large-diameter column, and the structures of two new components, named octapeptins A4 and B4, were deduced from the results of the fatty acid and amino acid analyses. © 1979.
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页码：313 / 320
页数：8
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