RELEVANCE OF VASCULAR PGI2 SYNTHASE TO VASCULAR PROSTACYCLIN PRODUCTION IN DAHL RATS SUSCEPTIBLE TO SALT-INDUCED HYPERTENSION

被引：10
作者：
UEHARA, Y
ISHIMITSU, T
IWAI, J
ISHII, M
SUGIMOTO, T
机构：
[1] Department of Internal Medicine, University of Tokyo, Tokyo, 113, 7-3-1 Hongo, Bunkyo-ku
[2] Brookhaven National Laboratory, New York, Upton
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 04期
关键词：
Dahl salt sensitive rats; PGI[!sub]2[!/sub]synthase; Prostacyclin; Salt hypertension; Vascular wall;
D O I：
10.1093/ajh/3.4.313
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
To assess the roles of prostacyclin (PGI2) synthase in vascular PGI2generation, the enzymatic activity was examined in the mesenteric artery of Dahl S rats in the prehypertensive or hypertensive stage. Elevation of blood pressure in Dahl S rats was accompanied by an increase of vascular PGI2synthase activity. The enzymatic activity was positively correlated to the blood pressure value. Similarly, impaired vascular capacity to generate PGI2/which was observed in prehypertensive Dahl S rats, was restored to the control level of Dahl R rats with the elevation of blood pressure. These data indicate that vascular PGI2synthase activity is increased with blood pressure elevation, thereby contributing to the restoration of vascular capacity to generate PGI2in Dahl S rats. © 1990 by the American Journal of Hypertension, Ltd.
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页码：313 / 316
页数：4
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