COMPARISON OF THE INHIBITION OF METHOTREXATE-SENSITIVE AND METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI CELL-CULTURES WITH PURIFIED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(3-SUBSTITUTED-PHENYL)-S-TRIAZINES - USE OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN MAKING INFERENCES ABOUT THE MECHANISM OF RESISTANCE AND THE STRUCTURE OF THE ENZYME INSITU COMPARED WITH THE ENZYME INVITROUA

被引：31

作者：

COATS, EA ^{[1
]}

GENTHER, CS ^{[1
]}

DIETRICH, SW ^{[1
]}

GUO, Z ^{[1
]}

HANSCH, C ^{[1
]}

机构：

[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 12期

关键词：

D O I：

10.1021/jm00144a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1422 / 1429

页数：8

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