TREATMENT, RESECTION AND ETHANOL INJECTION IN HEPATOCELLULAR-CARCINOMA - A RETROSPECTIVE ANALYSIS OF SURVIVAL IN 391 PATIENTS WITH CIRRHOSIS

被引：252

作者：

LIVRAGHI, T

BOLONDI, L

BUSCARINI, L

COTTONE, M

MAZZIOTTI, A

MORABITO, A

TORZILLI, G

BARBARA, L

BOUZARI, H

CAPUSSOTTI, L

CALVI, A

CATURELLI, E

COLOMBO, M

TOMMASINI, M

DOCI, R

GENNARI, L

FASSATI, L

FORNARI, F

FRIGERIO, F

GARBAGNATI, F

GOZZETTI, G

LAZZARONI, S

MARCHIORI, M

NICOLI, N

MARIN, G

MONTORSI, M

PEZZUOLI, G

PARISI, P

RAPACCINI, GL

RICCI, S

ROVERSI, RA

ROMANI, F

ROSSI, P

SALMI, A

TADDEI, G

VETTORI, C

机构：

[1] HOSP VIMERCATE,SERV RADIOL,MILAN,ITALY

[2] UNIV BOLOGNA,MED CLIN 1,I-40126 BOLOGNA,ITALY

[3] HOSP PIACENZA,DIV MED 1,PIACENZA,ITALY

[4] UNIV PALERMO,MED CLIN R,PALERMO,ITALY

[5] UNIV BOLOGNA,CHIRURG CLIN,I-40126 BOLOGNA,ITALY

[6] UNIV MILAN,IST BIOMETRIA,I-20122 MILAN,ITALY

[7] HOSP LODI,DIV CHIRURG GEN,LODI,ITALY

[8] MAURIZIANO HOSP,DIV CHIRURG GEN 2,TURIN,ITALY

[9] HOSP VARESE,DIV CHIRURG 2,VARESE,ITALY

[10] HOSP SAN GIOVANNI ROTONDO,DIV GASTROENTEROL,SAN GIOVANNI ROTO,ITALY

[11] UNIV MILAN,IST MED INTERNA,I-20122 MILAN,ITALY

[12] IST NAZL TUMORI,DIV ONCOL CHIRURG A,I-20133 MILAN,ITALY

[13] UNIV MILAN,IST CHIR SPERIMENTALE,I-20122 MILAN,ITALY

[14] IST NAZL TUMORI,IST RADIOL,I-20133 MILAN,ITALY

[15] HOSP CLUSONE,DIV MED,CLUSONE,ITALY

[16] UNIV VERONA,CHIRURG CLIN,I-37100 VERONA,ITALY

[17] HOSP PADOVA,DIV MED 2,PADUA,ITALY

[18] UNIV MILAN,IST CHIRURG GEN,I-20122 MILAN,ITALY

[19] CATHOLIC UNIV ROMA,MED CLIN,ROME,ITALY

[20] BELLARIA HOSP,SERV RADIOL,BOLOGNA,ITALY

[21] NIGUARDA HOSP,DIV CHIRURG 2,MILAN,ITALY

[22] UNIV MILAN,IST RADIOL,I-20122 MILAN,ITALY

[23] FATEBENEFRATELLI HOSP,DIV GEN MED,BRESCIA,ITALY

[24] UNIV VERONA,IST RADIOL,I-37100 VERONA,ITALY

[25] HOSP VIMERCATE,SERV RADIOL,VIMERCATE,ITALY

来源：

JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 05期

关键词：

LIVER TUMORS; NATURAL HISTORY; PERCUTANEOUS ETHANOL INJECTION; SURGERY;

D O I：

10.1016/0168-8278(95)80445-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: This retrospective study was undertaken to obtain information relevant to the therapeutic strategy in single hepatocellular carcinoma associated with Child's A and B cirrhosis. Methods: From a total of 1108 consecutive patients with hepatocellular carcinoma, 391 patients with single, small (less than or equal to 5 cm) hepatocellular carcinoma (260 in Child A class and 131 in Child B class) were observed: 120 were treated by surgical resection, 155 by percutaneous ethanol injection and 116 were untreated, The end point of the study was 3-year survival, The log rank test was used to compare survival among the different groups. Results: In the Child A group the cumulative 3-year survival was 79% for surgery, 71% for percutaneous ethanol injection and 26% for no treatment (p<0.001 for surgery versus no treatment, p<0.001 for percutaneous ethanol injection vs no treatment). In patients comparable to the surgical group, i.e. potentially operable, survival was 80% for percutaneous ethanol injection and 30% for no treatment, In the Child B group the 3-year survival was 40% for surgery, 41% for percutaneous ethanol injection and 13% for no treatment (p<0.01 for surgery vs no treatment and p<0.001 for percutaneous ethanol injection vs no treatment). Conclusions: Surgery and percutaneous ethanol injection improve survival in single hepatocellular carcinoma associated with Child A and B cirrhosis compared to untreated patients in the same Child class, A controlled study to identify factors affecting the choice of treatment is justified.

引用

页码：522 / 526

页数：5

共 29 条

[1] LIVER RESECTION VERSUS TRANSPLANTATION FOR HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS [J].