LANSOPRAZOLE REDUCES PREOPERATIVE GASTRIC FLUID ACIDITY AND VOLUME IN CHILDREN

被引:21
作者
MIKAWA, K
NISHINA, K
MAEKAWA, N
ASANO, M
OBARA, H
机构
[1] Department of Anaesthesiology, Kobe University School of Medicine, Chuo-ku, Kobe, 650
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1995年 / 42卷 / 06期
关键词
ANESTHESIA; PEDIATRIC; COMPLICATIONS; ASPIRATION; GASTROINTESTINAL TRACT; GASTRIC FLUID VOLUME; GASTRIC PH; PREMEDICATION; LANSOPRAZOLE;
D O I
10.1007/BF03011682
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The purpose of this study was to explore the efficacy of lansoprazole, a proton pump inhibitor, in reducing the acidity and volume of gastric aspirate in children immediately following the induction of anaesthesia. One hundred healthy in-patients aged 3-11 yr undergoing elective surgery were randomly allocated to four groups (n = 25 each): lansoprazole-lansoprazole, placebo-placebo, placebo-lansoprazole, and lansoprazole-placebo. For each treatment regimen, the first medication was administered at 9:00 pm on the night before surgery and the second at 5:30 am on the morning of the day of surgery (three hours preoperatively). The dose of lansoprazole was 30 mg (approximately 1.4 mg . kg(-1) mean). Children were offered 10 ml . kg(-1) apple juice three hours before induction of anaesthesia. After induction of anaesthesia and tracheal intubation, gastric fluid was aspirated through a large-bore, multiorifice orogastric tube and analyzed for pH and totalfluid volume. Lansoprazole increased gastric fluid pH and decreased gastric fluid volume regardless of whether it was administered before or after placebo. Two consecutive doses of lansoprazole was the most effective means of increasing the pH and reducing the volume of gastric aspirate; in this group, there were no subjects with gastric aspirate volume >0.4 ml . kg(-1) and pH <2.5. Oral lansoprazole, at least 30 mg, given on the night before surgery or on the morning of surgery will improve the gastric environment at the time of induction of paediatric anaesthesia. The most effective regimen was two doses (at bedtime and on the morning) of lansoprazole.
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页码:467 / 472
页数:6
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