COMPARATIVE-STUDY OF INVITRO INHIBITION OF ACTIVATION OF THE CLASSICAL AND ALTERNATIVE PATHWAYS OF HUMAN-COMPLEMENT BY THE MAGNESIUM AND SODIUM-SALTS OF THE ANTIINFLAMMATORY PEPTIDE N-ACETYL-ASPARTYL-GLUTAMIC ACID (NAAGA)

被引:7
作者
FEUILLARD, J [1 ]
MAILLET, F [1 ]
GOLDSCHMIDT, P [1 ]
WEISS, L [1 ]
KAZATCHKINE, MD [1 ]
机构
[1] HOP BROUSSAIS,SEROL INFECT & VIROL LAB,F-75674 PARIS 14,FRANCE
来源
AGENTS AND ACTIONS | 1991年 / 32卷 / 3-4期
关键词
D O I
10.1007/BF01980896
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The inhibitory activity of the sodium salt of the anti-inflammatory peptide N-acetyl-aspartyl-glutamic acid (NAAGA) on activation of the classical and alternative pathways of human complement was compared with that of the clinically used magnesium salt of NAAGA (NAAGA-Mg). Sodium salt of NAAGA (NAAGA-Na) inhibited both pathways of activation in a dose-dependent manner at concentration ranging from 1 to 10 mM by acting on formation and/or function of the C3 convertases as shown by the inhibitory capacity of the peptide on the release of the C3 cleavage fragment C3b and C3a. NAAGA-Na was as effective as NAAGA-Mg in inhibiting classical pathway activation at concentration above 10 mM. NAAGA-Na was more effective than NAAGA-Mg in inhibiting the alternative pathway since the sodium salt did not interfere with Mg-dependent formation of the alternative pathway C3 convertase.
引用
收藏
页码:343 / 346
页数:4
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