INHIBITORY EFFECTS OF 2'-FLUORINATED ARABINOSYL-PYRIMIDINE NUCLEOSIDES ON WOODCHUCK HEPATITIS-VIRUS REPLICATION IN CHRONICALLY INFECTED WOODCHUCKS

被引：53
作者：
FOUREL, I
HANTZ, O
WATANABE, KA
JACQUET, C
CHOMEL, B
FOX, JJ
TREPO, C
机构：
[1] INSERM,U271,UNITE RECH HEPATITES SIDA & RETROVIRUS HUMAINS,151 COURS A THOMAS,F-69424 LYONS,FRANCE
[2] ECOLE NATL VET,F-69280 MARCY LETOILE,FRANCE
[3] MEM SLOAN KETTERING CANC CTR,ORGAN CHEM LAB,NEW YORK,NY 10021
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 03期
关键词：
D O I：
10.1128/AAC.34.3.473
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.
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收藏
页码：473 / 475
页数：3
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