DOPAMINE-RELATED TETRAHYDROISOQUINOLINES - SIGNIFICANT URINARY-EXCRETION BY ALCOHOLICS AFTER ALCOHOL-CONSUMPTION

被引：159

作者：

COLLINS, MA ^{[1
]}

NIJM, WP ^{[1
]}

BORGE, GF ^{[1
]}

TEAS, G ^{[1
]}

GOLDFARB, C ^{[1
]}

机构：

[1] VET ADM HOSP,PSYCHIAT SERV,HINES,IL 60141

来源：

SCIENCE | 1979年 / 206卷 / 4423期

关键词：

D O I：

10.1126/science.505002

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Concentrations of dopamine-related tetrahydroisoquinolines (salsolinol and O-methylated salsolinol) were significantly higher in the daily urine samples of alcoholic subjects admitted for alcohol detoxification than in the daily urine samples of nonalcoholic control subjects. Salsolinol concentrations in alcoholic subjects appeared to drop to trace (control) values 2 to 3 days after admission, following the disappearance of ethanol and its reactive metabolite acetaldehyde from the blood. These results indicate that physiologically active tetrahydroisoquinolines increase in humans during long-term alcohol consumption, presumably because of acetaldehyde's direct condensation with catecholamines. The presence of these or similar condensation products in the urine could be useful as clinical indicators of prior blood acetaldehyde concentrations in chronic alcoholics. Copyright © 1979 AAAS.

引用

页码：1184 / 1186

页数：3

共 32 条

[1]

AZEVEDO I, 1977, NAUNYNSCHMIEDEBERGS, V30, P139

[2] TISSUE CATECHOLAMINES AND POTENTIAL TETRAHYDROISOQUINOLINE ALKALOID METABOLITES - GAS-CHROMATOGRAPHIC ASSAY METHOD WITH ELECTRON-CAPTURE DETECTION [J].