CYCLIC AMP-DEPENDENT EXPRESSION OF THE HEAVY NEUROFILAMENT (NF-H) POLYPEPTIDE IN DIFFERENTIATING NEUROBLASTOMA-CELLS

被引：13

作者：

BREEN, KC ^{[1
]}

ANDERTON, BH ^{[1
]}

机构：

[1] INST PSYCHIAT, LONDON SE5 8AF, ENGLAND

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 7卷 / 02期

关键词：

C1300; Cyclic AMP; Gene expression; Neurofilament; RNA;

D O I：

10.1016/0169-328X(90)90093-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dibutyryl cyclic AMP (dbcAMP) treatment of Neuro 2A neuroblastoma cells induces cell differentiation and neurite outgrowth. Undifferentiated cells express the heavy neurofilament polypeptide (NF-H) at a low level. Following differentiation, there is a large increase in its expression due to an increase in the corresponding cellular mRNA. A similar increase is seen following forskolin treatment of the cells indicating that the increase in NF-H expression is cyclic AMP-dependent. The increase in mRNA is due to an increase in gene transcription as demonstrated by a nuclear run-off assay. © 1990.

引用

页码：161 / 165

页数：5

共 25 条

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[2]

BRAUMANN T, 1986, J NEUROCHEM, V47, P912

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