TRICYCLIC ANTIDEPRESSANTS AND CARDIAC CONDUCTION - CHANGES IN VENTRICULAR AUTOMATICITY

被引：21

作者：

BAUM, T ^{[1
]}

PETERS, JR ^{[1
]}

BUTZ, F ^{[1
]}

MUCH, DR ^{[1
]}

机构：

[1] WYETH LABS INC, CARDIOVASC PHARMACOL SECT, RADNOR, PA 19087 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1976年 / 39卷 / 02期

关键词：

D O I：

10.1016/0014-2999(76)90142-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ventricular dysrhythmias result from changes in the automaticity or the conduction properties of the specialized conduction system. Since tricyclic antidepressants have been reported to cause ventricular dysrhythmias in humans and experimental animals, the effect of these substances on ventricular automaticity was studied. Ventricular rhythm was produced in anesthetized dogs by blocking atrioventricular conduction. Low doses of imipramine, amitriptyline and nortriptyline resulted in small but significant increases in automaticity. Relatively high doses of these agents suppressed automaticity markedly. These changes could play a role in the development of dysrhythmias.

引用

页码：323 / 329

页数：7

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