Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300

被引:7
作者
Al-Halbosiy, Mohammad M. F. [1 ]
Thabit, Zaid A. [1 ]
Al-Qaysi, Safaa Al-Deen A. S. [2 ]
Moussa, Tarek A. A. [3 ]
机构
[1] Univ AL Nahrain, Biotechnol Res Ctr, Baghdad, Iraq
[2] Univ Baghdad, Dept Biol, Coll Sci Women, Baghdad, Iraq
[3] Cairo Univ, Dept Bot & Microbiol, Fac Sci, Giza 12613, Egypt
关键词
Anticancer; Anti-inflammatory; Antioxidant; Antileishmanial; Brachybacterium phenoliresistens; Levan;
D O I
10.21123/bsj.2018.15.3.0238
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens KX139300. These were done via study the antioxidant, anti-inflammatory, anticancer and antileishmanial activities in vitro. The antioxidant levan was shown 80.9% activity at 1250 mu g/mL concentration. The efficient anti-inflammatory activity of 88% protein inhibition was noticed with levan concentration at 35 mu g/mL. The cytotoxic activity of levan at 2500 mu g/mL concentration showed a maximum cytotoxic effect on L20B cell line and promastigotes of Leishmani tropica. Levan has dose-dependent anticancer and antileishmanial activities. An addition to the antioxidant, anti-inflammatory and anticancer potential activities of levan, it can be concluded that levan produced from B. phenoliresistens can efficiently be applied as an antileishmanial agent.
引用
收藏
页码:238 / 243
页数:6
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