Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300

被引：8

作者：

Al-Halbosiy, Mohammad M. F. ^{[1
]}

Thabit, Zaid A. ^{[1
]}

Al-Qaysi, Safaa Al-Deen A. S. ^{[2
]}

Moussa, Tarek A. A. ^{[3
]}

机构：

[1] Univ AL Nahrain, Biotechnol Res Ctr, Baghdad, Iraq

[2] Univ Baghdad, Dept Biol, Coll Sci Women, Baghdad, Iraq

[3] Cairo Univ, Dept Bot & Microbiol, Fac Sci, Giza 12613, Egypt

来源：

BAGHDAD SCIENCE JOURNAL | 2018年 / 15卷 / 03期

关键词：

Anticancer; Anti-inflammatory; Antioxidant; Antileishmanial; Brachybacterium phenoliresistens; Levan;

D O I：

10.21123/bsj.2018.15.3.0238

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens KX139300. These were done via study the antioxidant, anti-inflammatory, anticancer and antileishmanial activities in vitro. The antioxidant levan was shown 80.9% activity at 1250 mu g/mL concentration. The efficient anti-inflammatory activity of 88% protein inhibition was noticed with levan concentration at 35 mu g/mL. The cytotoxic activity of levan at 2500 mu g/mL concentration showed a maximum cytotoxic effect on L20B cell line and promastigotes of Leishmani tropica. Levan has dose-dependent anticancer and antileishmanial activities. An addition to the antioxidant, anti-inflammatory and anticancer potential activities of levan, it can be concluded that levan produced from B. phenoliresistens can efficiently be applied as an antileishmanial agent.

引用

页码：238 / 243

页数：6

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