PD-1 and PD-L1 Inhibitors: Activity as Single Agents and Potential Biomarkers in Non-Small Cell Lung Cancer

被引：0

作者：

Goldberg, Sarah B.

机构：

来源：

AMERICAN JOURNAL OF HEMATOLOGY-ONCOLOGY | 2015年 / 11卷 / 09期

关键词：

Non-small cell lung cancer; immunotherapy; PD-1; PD-L1;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotherapy has recently become a part of standard-of-care treatment for non-small cell lung cancer (NSCLC) with the recent FDA approval of nivolumab in the second-line setting for patients with advanced squamous cell carcinoma. Several other immunotherapeutics are currently under investigation for the treatment of NSCLC, including those that inhibit PD-1 and PD-L1. Data from early clinical trials show encouraging results with several of these drugs, particularly in terms of durability of response and tolerability. This review will provide an overview of the agents that inhibit the PD-1 axis that are currently furthest along in clinical development for NSCLC. It will also discuss challenges in interpreting the data in the setting of a complicated biomarker development strategy, as well as common toxicities seen with immunotherapy.

引用

页码：10 / 13

页数：4

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