INTERFERON-ALPHA-II ACTION OF SODIUM-CHANNELS IN HUMAN NEUROBLASTOMA IMR-32 CELLS

被引：0
|
作者：
VIATCHENKOKARPINSKI, SV [1 ]
POGORELAJA, NH [1 ]
MAGURA, IS [1 ]
ROZHMANOVA, OM [1 ]
MATZUKA, GH [1 ]
SENIUK, OF [1 ]
机构：
[1] UKRAINIAN ACAD SCI,INST MOLEC BIOL & GENET,KIEV,UKRAINE
来源：
BIOLOGICHESKIE MEMBRANY | 1992年 / 9卷 / 10-11期
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D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It was shown that human interferon alphaII modulates sodium current in human neuroblastoma cells by changing the kinetic parameters of fast sodium current. The maximum effect was observed 5-10 min after interferon application. The action of 2'-5'-oligoadenylate on sodium current is identical to that of interferon alphaII. The effect of 2'-5'-oligoadenylate is enhanced as its concentration in pipette solution rises. The same effect of 2'-5'-oligoadenylate was demonstrated in mouse neuroblastoma N1E-115 cells.
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页码：1159 / 1160
页数：2
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