CYCLOSPORINE-A PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY IN THE BRAIN

被引：164
|
作者：
SHIGA, Y
ONODERA, H
MATSUO, Y
KOGURE, K
机构：
[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai
来源：
BRAIN RESEARCH | 1992年 / 595卷 / 01期
关键词：
TRANSIENT FOCAL BRAIN ISCHEMIA; CEREBRAL INFARCTION; BRAIN EDEMA; CYCLOSPORINE-A;
D O I：
10.1016/0006-8993(92)91465-Q
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex perfused by the middle cerebral artery (MCA) and infarct size were decreased compared with those in olive oil treated control rats. These results suggest that CsA is beneficial in reducing ischemia-reperfusion injury, possibly by the suppression of immunological reactions.
引用
收藏
页码：145 / 148
页数：4
相关论文
共 50 条
  • [21] Remifentanil protects uterus against ischemia-reperfusion injury in rats
    Atalay, Yunus Oktay
    Aktas, Serap
    Sahin, Sadik
    Kucukodaci, Zafer
    Ozakpinar, Ozlem Bingol
    ACTA CIRURGICA BRASILEIRA, 2015, 30 (11) : 756 - 761
  • [22] Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury
    Kishi, Seiji
    Campanholle, Gabriela
    Gohil, Vishal M.
    Perocchi, Fabiana
    Brooks, Craig R.
    Morizane, Ryuji
    Sabbisetti, Venkata
    Ichimura, Takaharu
    Mootha, Vamsi K.
    Bonventre, Joseph V.
    EBIOMEDICINE, 2015, 2 (09): : 1090 - 1101
  • [23] Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury
    Ivanov, Milan
    Brkic, Predrag
    Vajic, Una-Jovana
    Mihailovic-Stanojevic, Nevena
    Milacic, Davorka
    Jovovic, Djurdjica
    Karanovic, Danijela
    Djelic, Marina
    Jeremic, Rada
    Miloradovic, Zoran
    UNDERSEA AND HYPERBARIC MEDICINE, 2020, 47 (01) : 21 - 30
  • [24] Carnosol protects against renal ischemia-reperfusion injury in rats
    Zheng, Yi
    Zhang, Yong
    Zheng, Yichun
    Zhang, Nan
    EXPERIMENTAL ANIMALS, 2018, 67 (04) : 545 - 553
  • [25] Melatonin protects against gastric ischemia-reperfusion injury in rats
    DelaLastra, CA
    Cabeza, J
    Motilva, V
    Martin, MJ
    JOURNAL OF PINEAL RESEARCH, 1997, 23 (02) : 47 - 52
  • [26] Cardiac mTOR protects the heart against ischemia-reperfusion injury
    Aoyagi, Toshinori
    Kusakari, Yoichiro
    Xiao, Chun-Yang
    Inouye, Brendan T.
    Takahashi, Masaya
    Scherrer-Crosbie, Marielle
    Rosenzweig, Anthony
    Hara, Kenta
    Matsui, Takashi
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2012, 303 (01): : H75 - H85
  • [27] Gossypin Protects Against Renal Ischemia-Reperfusion Injury in Rats
    Tanyeli, Ayhan
    Eraslan, Ersen
    Guler, Mustafa Can
    Kurt, Nezahat
    Akaras, Nurhan
    KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2020, 26 (01) : 89 - 96
  • [28] Hydralazine protects against renal ischemia-reperfusion injury in rats
    Li, Yong
    Hou, Daorong
    Chen, Xuguan
    Zhu, Jingfeng
    Zhang, Ruyi
    Sun, Wei
    Li, Peng
    Tian, Yunfan
    Kong, Xiangqing
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 843 : 199 - 209
  • [29] Intralipid Protects Late Pregnant Mouse Heart Against Ischemia/Reperfusion Injury More Efficiently than Cyclosporine-A
    Li, Jingyuan
    Amjedi, Marjan
    Nadadur, Sandhya
    Eghbali, Mansoureh
    CIRCULATION, 2011, 124 (21)
  • [30] Inhibition of poly(ADP-ribosyl)ation protects brain against ischemia-reperfusion injury
    不详
    PHARMACOLOGICAL REPORTS, 2005, 57 (03) : 428 - 428
12345