ROLE OF OXIDATIVE STRESS IN FORMATION MECHANISMS OF GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE II AND ITS CORRECTION

Present study was aimed to investigate the role of oxidative stress in the formation mechanisms of gastroesophageal reflux disease in patients with diabetes mellitus type II and to develop methods for its correction. Two groups of people with mild and moderate severe diabetes mellitus type II with concomitant gastroesophageal reflux disease were observed. The first included 28 patients aged 35 to 45 years who received standard treatment and actovegin. The second group consisted of 25 patients of the same sex and age who received only basic therapy. The third experimental group included 27 patients with gastroesophageal reflux disease without concomitant pathology of the same age group. In all patients, the level of antioxidant protection, lipid peroxidation and regional blood flow in the celiac trunk were determined. In the course of the study, we found that while treating patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease both in patients of the first and second groups, a clear tendency of decreasing the clinical manifestations of the disease was determined, and the glycemic index was normalized. We found that after a 4-week course of therapy in patients of both treatment groups, the indices of antioxidant protection of esophageal mucosa increased, and the indices of lipid peroxidation decreased. In patients the diameter of the celiac trunk increased, and the blood flow velocity in it improved. While in patients of the second control group, who received only the standard treatment, the dynamics of blood flow in the celiac trunk was significantly less. The introduction of actovegin in the standard treatment regimen of patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease reduces the timing of the onset of clinical remission of both the underlying disease and concomitant disease, and also increases the activity of antioxidant protection of the esophagus.