SIMULTANEOUS DETERMINATION OF OTILONIUM BROMIDE AND DIAZEPAM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：5
作者：
SANTONI, G
FABBRI, L
MURA, P
RENZI, G
GRATTERI, P
PINZAUTI, S
机构：
[1] UNIV FLORENCE,DIPARTIMENTO SCI FARMACEUT,VIA G CAPPONI 9,I-50121 FLORENCE,ITALY
[2] STABILIMENTO CHIM FARMACEUT MIL,FLORENCE,ITALY
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 71卷 / 1-2期
关键词：
OTILONIUM BROMIDE; DIAZEPAM; REVERSED-PHASE HPLC; SIMULTANEOUS DETERMINATION; TABLETS;
D O I：
10.1016/0378-5173(91)90061-R
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A reversed-phase high performance liquid chromatographic method for the simultaneous determination of otilonium bromide and diazepam in tablets has been developed. Owing to the residual free silanol groups on the modified silica surface, otilonium bromide eluted from the reversed-phase column without retardation effects, using a methoanol-water eluent containing tetramethylammonium bromide and acetic acid. The effects of the tetramethylammonium bromide concentration on the capacity and symmetry factors of otilonium bromide and diazepam were investigated.
引用
收藏
页码：1 / 5
页数：5
相关论文
共 15 条
[1]   RETENTION MECHANISM FOR REVERSED-PHASE ION-PAIR LIQUID-CHROMATOGRAPHY [J].
BIDLINGMEYER, BA ;
DEMING, SN ;
PRICE, WP ;
SACHOK, B ;
PETRUSEK, M .
JOURNAL OF CHROMATOGRAPHY, 1979, 186 (DEC) :419-434
[2]   SEPARATION OF IONIC COMPOUNDS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - AN UPDATE OF ION-PAIRING TECHNIQUES [J].
BIDLINGMEYER, BA .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1980, 18 (10) :525-539
[3]  
CORTI P, 1990, PHARM ACTA HELV, V65, P189
[4]   A RECENT REVIEW OF SECONDARY MOBILE PHASE MODIFIERS USED TO ENHANCE THE CHROMATOGRAPHIC ANALYSIS OF PHARMACEUTICALS [J].
GILPIN, RK ;
YANG, SS ;
WERNER, G .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1988, 26 (08) :388-400
[5]   HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF PILOCARPINE, ISOPILOCARPINE, PILOCARPIC ACID AND ISOPILOCARPIC ACID [J].
GOMEZGOMAR, A ;
GONZALEZAUBERT, M ;
COSTASEGARRA, J .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1989, 7 (12) :1729-1734
[6]   DETERMINATION OF HYDROXYL-GROUPS AND WATER-CONTENT IN SILICA BY NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].
HOLIK, M ;
MATEJKOVA, B .
JOURNAL OF CHROMATOGRAPHY, 1981, 213 (01) :33-39
[7]  
KIEL JS, 1985, J CHROMATOGR, V320, P313
[8]  
LONARDI S, 1980, B CHIM FARM, V6, P339
[9]   ROLE OF BUFFER CATIONS IN THE REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF AROMATIC-AMINES .1. METHANOL-RICH ELUENTS [J].
PAPP, E ;
VIGH, G .
JOURNAL OF CHROMATOGRAPHY, 1983, 259 (01) :49-58
[10]   ROLE OF BUFFER CATIONS IN THE REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF AROMATIC-AMINES .2. METHANOL-LEAN ELUENTS [J].
PAPP, E ;
VIGH, G .
JOURNAL OF CHROMATOGRAPHY, 1983, 282 (DEC) :59-70
12