STUDIES OF CHROMENES .10. OXIRANES OF NITROCHROMENES

被引：26

作者：

BROWN, PE

LEWIS, RA

机构：

[1] Department of Chemistry, The University

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 05期

关键词：

D O I：

10.1039/p19920000573

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of stable oxiranes of 5- and 7-nitro-, and 5,7-dinitro- 2,2-dimethyl(chromenes and of 7-2H-ethoxycarbonylamino)-2,2-dimethyl-5-nitro-2H-chromene are described. Thermal cyclisation of the precursor phenyl prop-2-ynyl ethers proceeds in good yield but in the case of the dinitrophenyl ether the products are highly solvent dependent. The compounds are of interest as possible antitumour alkylating agents that are activated by bioreduction to extremely reactive oxiranes.

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页码：573 / 577

页数：5

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