PRESENCE OF 2-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1,2-DIMETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, NOVEL ENDOGENOUS AMINES, IN PARKINSONIAN AND NORMAL HUMAN BRAINS

被引：87

作者：

NIWA, T

TAKEDA, N

YOSHIZUMI, H

TATEMATSU, A

YOSHIDA, M

DOSTERT, P

NAOI, M

NAGATSU, T

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 464,JAPAN

[2] NAGOYA UNIV,BRANCH HOSP,DEPT INTERNAL MED,NAGOYA,AICHI 464,JAPAN

[3] MEIJO UNIV,FAC PHARM,NAGOYA,AICHI 468,JAPAN

[4] JICHI MED SCH,DEPT NEUROL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[5] FARMITALIA CARLO ERBA SPA,RES & DEV,MILAN,ITALY

[6] NAGOYA INST TECHNOL,DEPT BIOSCI,NAGOYA,AICHI 466,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91831-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were identified for the first time as novel endogenous amines in parkinsonian and normal human brains by gas chromatography-mass spectrometry. It is of interest that these tetrahydroisoquinolines are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which produces Parkinson's disease. © 1991.

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收藏

页码：603 / 609

页数：7

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