COLLAGEN-METABOLISM IN GYNECOLOGIC PATIENTS - CHANGES IN THE CONCENTRATION OF THE AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN IN SERUM

被引:16
作者
PUISTOLA, U
RISTELI, L
RISTELI, J
KAUPPILA, A
机构
[1] UNIV OULU,DEPT MED BIOCHEM,COLLAGEN RES UNIT,SF-90220 OULU,FINLAND
[2] UNIV OULU,DEPT CLIN CHEM,SF-90220 OULU,FINLAND
基金
英国医学研究理事会; 芬兰科学院;
关键词
aminoterminal propeptide of type III procollagen; endometriosis; Menstrual cycle; ovarian cysts; salpingo-oophoritis;
D O I
10.1016/0002-9378(90)90707-E
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
We have previously found the serum concentration of the aminoterminal propeptide of type III procollagen, an indicator of collagen metabolism, to be increased in advanced ovarian cancer. In this study we measured the serum aminoterminal propeptide of type III procollagen concentration in healthy women during the menstrual cycle and in patients with salpingo-oophoritis, leiomyomas, endometriosis, and benign ovarian tumors. The concentration was higher in the luteal phase than that in the follicular phase, suggesting an association of collagen metabolism with ovarian steroid hormones. Severe salpingo-oophoritis increased the serum level of the aminoterminal propeptide of type III procollagen with a decrease to normal during recovery. Elevated values were occasionally seen in endometriosis and leiomyomas. These findings indicate that the aminoterminal propeptide of type III procollagen is a relatively unspecific indicator of ovarian carcinoma. © 1990.
引用
收藏
页码:1276 / 1281
页数:6
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