A COMPARISON OF LIDOCAINE AND LIDOCAINE METOCLOPRAMIDE COMBINATION IN PREVENTION OF PAIN DURING INJECTION OF PROPOFOL

BACKGROUND: Combination of lidocaine hydrochloride and metoclopramide is most effective for prevention of pain during propofol injection than by lidocaine hydrochloride alone. METHODS: Ninety healthy patients of both sex aged between 5-50 years ASA physical status I & II, scheduled for short surgical procedures. Patients in group 1(n = 30) were induced with propofol 2-2.5 mg/kg i.v, patients in group 2(n = 30) were induced with propofol 2-2.5mg/ kg i.v and lidocaine hydrochloride 20 mg (Preservative free) i.v, and group 3(n = 30) patients were induced with propofol 2-2.5mg/kg i.v and lidocaine hydrochloride 20mg (Preservative free) and metoclopramide 10 mg. Pain was assessed at 0, 5 and 10 seconds by verbal pain scale. The mean blood pressure (MBP) and heart rate (HR) were recorded as the base value, before induction and at 0, 5 and 10 seconds respectively. RESULTS: Pain after administration of group 1 shows increase as the duration of time elapsed, at the time of administration it is 83.33%, after 5 & 10 secs it had increased to 86.66% and 93.33% respectively. Pain after administration of group 2 cases increased as the time elapsed at the time of administration it is 66.66% and 5 & 10 secs it is 80.00% and 93.33% respectively. Pain after administration of group 3 cases shows decreased incidence of pain as the time lapsed in comparison with group 1 & 2 respectively. CONCLUSION: Combination of lidocaine hydrochloride and metoclopramide is most effective for prevention of pain during propofol injection than by lidocaine hydrochloride alone.