ZINC MEDIATED ADDITION OF ACTIVE HALIDES TO A GLYCINE CATION EQUIVALENT - SYNTHESIS OF N-BOC-L-PROPARGYLGLYCINE

被引：11
作者：
ABOOD, NA
NOSAL, R
机构：
[1] Department of Chemistry Searle Research and Development, Skokie
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 22期
关键词：
D O I：
10.1016/S0040-4039(00)73067-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of allylic, benzylic and propargylic halides with zinc in the presence of the glycine cation equivalent, methyl N-Boc-2-acetoxyglycine, affords Boc protected amino acid derivatives in high yield. Resolution of methyl N-Boc-propargylglycine with alpha-chymotrypsin affords N-Boc-L-propargylglycine in 99% e.e..
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页码：3669 / 3672
页数：4
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