LANDAU-KLEFFNER SYNDROME - EPILEPTIC ACTIVITY IN THE AUDITORY-CORTEX

被引：50

作者：

PAETAU, R ^{[1
]}

KAJOLA, M ^{[1
]}

KORKMAN, M ^{[1
]}

HAMALAINEN, M ^{[1
]}

GRANSTROM, ML ^{[1
]}

HARI, R ^{[1
]}

机构：

[1] UNIV HELSINKI,CHILDRENS CASTLE HOSP,CHILD NEUROL CLIN,SF-00100 HELSINKI 10,FINLAND

来源：

NEUROREPORT | 1991年 / 2卷 / 04期

关键词：

ACQUIRED APHASIA; AUDITORY AGNOSIA; EPILEPSY; LANGUAGE DOMINANCE; MAGNETOENCEPHALOGRAPHY;

D O I：

10.1097/00001756-199104000-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Landau-Kleffner syndrome (LKS) is characterized by electroencephalographic spike discharges and verbal auditory agnosia in previously healthy children. We recorded magnetoencephalographic (MEG) spikes in a patient with LKS, and compared their sources with anatomical information from magnetic resonance imaging. All spikes originated close to the left auditory cortex. The evoked responses were contaminated by spikes in the left auditory area and suppressed in the right - the latter responses recovered when the spikes disappeared. We suggest that unilateral discharges at or near the auditory cortex disrupt auditory discrimination in the affected hemisphere, and lead to suppression of auditory information from the opposite hemisphere, thereby accounting for the two main criteria of LKS.

引用

页码：201 / 204

页数：4

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