ACTIVATION OF PHOSPHATIDYLINOSITOL-3-KINASE BY INSULIN IS MEDIATED BY BOTH A-HUMAN AND B-HUMAN INSULIN-RECEPTOR TYPES

被引：17

作者：

CARRASCOSA, JM

VOGT, B

ULLRICH, A

HARING, HU

机构：

[1] INST DIABETESFORSCHUNG,MUNICH,GERMANY

[2] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90494-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of a phosphatidylinositol-3-kinase (PI-3-kinase) is one of the earliest consequences of insulin binding to the receptor. The human insulin receptor exists in two isoforms which differ in the length of the α-subunit (HIR-A = 719 aa, HIR-B = 731 aa). To test whether both isoforms transduce an insulin signal on PI-3-kinase we used rat-1-fibroblasts expressing HIR-A or HIR-B. We found that insulin stimulates 32P incorporation into PIP through both HIR-A and HIR-B to a similar extent (approx. 8-10 fold). © 1991.

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页码：123 / 127

页数：5

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